Genres: Anatomy. The science of genetics is less than years old, but its accomplishments within that short time have been astonishing. Gregor Mendel first described genes as abstract units of inheritance in ; his work was ignored and then rediscovered in Remarkably, less than 50 years later in , an international consortium of investigators deciphered the sequence of the 3 billion nucleotides in the human genome. Twentieth century genetics made it possible to identify individual genes and to understand a great deal about their functions.
Analysis of these data will result in a deeper understanding of the complex molecular interactions within and among vast networks of genes, proteins, and other molecules that help bring organisms to life.
Finding new methods and tools for analyzing these data will be a significant part of genetics in the twenty-first century. Our sixth edition of Genetics: From Genes to Genomes emphasizes both the core concepts of genetics and the cutting-edge discoveries, modern tools, and analytic methods that will keep the science of genetics moving forward. The authors of the sixth edition have worked together in revising every chapter in an effort not only to provide the most up-to-date information, but also to provide continuity and the clearest possible explanations of difficult concepts in one voice.
Important Notice: The digital edition of this book is missing some of the images or content found in the physical edition. How do some genes control the expression of others? How do genes interact to form gene networks? With its unique integration of genetics and molecular biology, Genetic Analysis probes fascinating questions such as these, detailing how our understanding of key genetic phenomena can be used to understand biological systems.
Opening with a brief overview of key genetic principles, model organisms, and epigenetics, the book goes on to explore the use of gene mutations and the analysis of gene expression and activity. A discussion of the interactions of genes during suppression, synthetic enhancement, and epistasis follows, which is then expanded into a consideration of genetic networks and personal genomics.
Drawing on the latest experimental tools, including CRISPR-Cas9 genome editing, microarrays, RNAi screens, and bioinformatics approaches, Genetic Analysis provides a state-of-the-art review of the field, but in a truly student-friendly manner.
It uses extended case studies and text boxes to augment the narrative, taking the reader right to the forefront of contemporary research, without losing its clarity of explanation and insight.
Back Continue. Rent or purchase for a fraction of the printed textbook price Easily highlight, take notes and search Download the free ReadAnywhere App for offline access and anytime reading Watch a quick video to learn more Note: the eBook does not include access to Connect. If your instructor assigned Connect, click the "Digital" tab. Rent for a fraction of the printed textbook price Rental transaction occurs through McGraw Hill's authorized rental partner.
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Check with your instructor to see if Connect is used in your course. Program Details. About the Author Michael Goldberg Dr. Michael Goldberg is a professor at Cornell University, where he teaches introductory. Affordability Find out more about our affordable course material programs. Want more information? Our Learning Technology Representatives can help. In the sequencing reaction, the enzyme incorporates into the new DNA strand individual nucleotides that have been chemically tagged with a fluorescent label.
As this happens, the nucleotide is excited by a light source, and a fluorescent signal is emitted and detected. The signal is different depending on which of the four nucleotides was incorporated. This method can generate 'reads' of nucleotides in a row and billions of reads at a time. To assemble the sequence of all the bases in a large piece of DNA such as a gene, researchers need to read the sequence of overlapping segments.
This allows the longer sequence to be assembled from shorter pieces, somewhat like putting together a linear jigsaw puzzle. In this process, each base has to be read not just once, but at least several times in the overlapping segments to ensure accuracy.
The disease-causing change may be as small as the substitution, deletion, or addition of a single base pair or as large as a deletion of thousands of bases. That international project was successfully completed in April , under budget and more than two years ahead of schedule. The sequence is not that of one person, but is a composite derived from several individuals. Therefore, it is a "representative" or generic sequence. To ensure anonymity of the DNA donors, more blood samples nearly were collected from volunteers than were used, and no names were attached to the samples that were analyzed.
Thus, not even the donors knew whether their samples were actually used. The Human Genome Project was designed to generate a resource that could be used for a broad range of biomedical studies. One such use is to look for the genetic variations that increase risk of specific diseases, such as cancer, or to look for the type of genetic mutations frequently seen in cancerous cells.
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